The survival of skin flap is an important aspect of plastic surgery and to increase the survival rate of the skin flap transplanted, many clinical and experimental researches have been carried out continuously upto this date.
As a result of those researches it was recently found that in the process of preparation for the skin flap, prostaglandin is synthesized and released by some physical stimulus, which in turn contributes to dilating the blood vessels and increasing the survival rate of the skin flap finally.
In this experiment the random skin flap pattern with PGE? and flurbiprofen, the most potent PG inhibitor known, were used and the effects of these two substances were relatively compared on the basis of reaction time. The following results were obtained.
1. In Group Ⅰ, PGE? was administered preoperatively and the survival rate of the skin flap was shown to be 72.4%, in Group Ⅱ, the average survival rate of 74.88% was obtained with PGE? given immediately after the operation. These two values showed significantly higher survival rate compared to that of the control group which yielded 66.38%, the group with PG E? given postoperatively showed slightly better survival rate than the group administered preoperatively.
2. In Group Ⅳ, flurbiprofen was given first preoperatively to inhibit prostaglandin synthesis, followed by PG E? administration just before performing the operation. This group resulted in the average survival rate of 60.56% showing significantly lower survival rate than the control group, but nevertheless, definitely higher rate than the group treated by flurbiprofen alone.
3. In Group Ⅴ, flurbiprofen was given preoperatively with PG E? administered immediately after the operation and the average survival rate of the flap was 77.25% showing a remarkable increase.
In conclusion PG E? administered immediately after the skin flap transplantation gains better survival rate than the ones with preoperative PG E?.
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